Mary&May Spicule Retinol PDRN Cream

Mary&May Spicule Retinol PDRN Cream — Product DescriptionResurface.

Regenerate. Firm.

The Mary&May Spicule Retinol PDRN Cream is a next-generation anti-aging treatment that combines three technologies rarely found together in one cream: marine-derived micro-spicules (natural microneedles), Nano Liposome Retinol, and CICA PDRN (Salmon DNA).Each works at a different level to visibly transform pores, wrinkles, and skin texture — without the harsh irritation typical of retinol products.

The 2,000 ppm micro-spicules (80–300μm — 1/40 the size of a pore) physically resurface the skin by channeling active ingredients deeper, creating a temporary plumping effect and improving pore density, depth, and area. The 1,000 ppm Nano Liposome Retinol accelerates cell turnover and collagen synthesis in a stable, low-irritation encapsulation. And CICA PDRN (Polydeoxyribonucleotide) repairs damaged cells, strengthens the collagen barrier, and calms any retinol-induced sensitivity simultaneously. 

Completed by a Safe 4X Formula — 2% Panthenol, Ceramide NP, Hyaluronic Acid, and Allantoin — for a formula that is powerful yet suitable even for sensitive skin.

Clinically Proven Results:

• Pore Depth improved 115.79% · Pore Area 121.61% · Pore Density 117.19%
• Eye Wrinkles reduced 112.24% · Smile Lines 110.20%
• Skin Texture improved 114.42%
• Skin Firmness improved 103.75%

Key Benefits:

• 2,000 ppm marine micro-spicules — physical resurfacing, pore refinement
• 1,000 ppm Nano Liposome Retinol — cell renewal, collagen boost, wrinkle reduction
• CICA PDRN — skin regeneration, barrier repair, soothes retinol irritation
• 2% Panthenol + Ceramide NP + HA + Allantoin — deep hydration and barrier protection
• Skin irritation tested — suitable for sensitive skin with gradual introduction

Skin Type: All skin types · especially oily, textured, aging, or uneven-tone skin

Evening only — retinol increases sun sensitivity. Apply after serum as the last step or before a final moisturizer. A mild tingling sensation from the spicules is normal and expected.

Do not combine in the same routine with AHA/BHA exfoliants, Vitamin C, or other retinol products. Beginners: start 2–3x per week and build up. Always wear SPF50+ the following morning.

How to Use:
In the evening, after cleansing and serum, take an appropriate amount and apply evenly across the face. Pat gently until absorbed. A mild tingling sensation is normal. Follow with moisturizer if needed. Always apply SPF the next morning.